Many studies have investigated the minority experiences of Muslim groups in North America, Europe, and Australia over the last decade since the terrorist attacks of September 11, 2001. However, few studies have examined their experiences in Asian contexts with pluralistic beliefs and practices, particularly related to Buddhism, Taiwanese folk religion, Daoism, and Confucianism, such as Taiwan. This study aims to investigate how international Muslim science students adjust to the research laboratories and society in Taiwan. Fourteen Muslim male science students from Indonesia were recruited for a qualitative interview. In terms of conventional content analysis, several of their adjustment issues were identified, including language barriers and adjustment issues related particularly to their religious issues, including gender roles in and outside of laboratories, inconvenient practices and social discrimination off campus. Two types of adaptation strategies were identified for dealing with these struggles, including Islamic beliefs and bicultural connections (e.g., gaining religious support from Taiwanese laboratory mates and advisors). The implications of this study and discussions regarding counseling, education, and research are included in this study as well.